---
title: "Progesterone Injections Guide | The Gender Hormone Clinic"
description: "Injectable progesterone isn't routine in UK gender-affirming care. Body-identical oral capsules are the standard."
url: https://thegenderhormoneclinic.com/patient-resources/medication-guides/progesterone-injections/
---

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PROGESTERONE · MEDICATION GUIDE

# Progesterone Injections therapy, a clear guide.

Patients sometimes ask about injectable progesterone, particularly those who've researched protocols used outside the UK. It isn't a standard route for gender-affirming care here: body-identical micronised progesterone, taken as oral capsules (Utrogestan or Gepretix), achieves clinical effect with much simpler administration and a strong UK evidence base.

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Available for gender care?

No, oral is the standard route

Standard alternative

Utrogestan or Gepretix (100-200 mg nightly)

Active ingredient

Body-identical micronised progesterone

If oral causes GI issues

Rectal administration of the same capsules

Cyclical option

200 mg × 14 days/month available

Brands

Utrogestan and Gepretix are clinically interchangeable

On this page[Overview](#ma-overview)[FAQ](#ma-faq)

GHC does not usually prescribe injectable progesterone for gender-affirming care; body-identical oral capsules are the standard. For how we use progesterone, see [feminising hormone therapy](https://thegenderhormoneclinic.com/transgender-hormone-therapy/transfeminine/) or our [non-binary care](https://thegenderhormoneclinic.com/transgender-hormone-therapy/non-binary/) page.

OVERVIEW

## What progesterone injections does, in plain English.

Both Utrogestan (Besins Healthcare) and Gepretix (Exeltis UK) are micronised progesterone soft capsules, body-identical to the progesterone the human body makes, and licensed in the UK as part of HRT. There is no clinically meaningful difference between them, so pharmacy substitution is common and safe.

If oral dosing causes drowsiness, dizziness, or GI side effects, your clinician can switch you to rectal administration of the same capsules without a new prescription. Some patients also use a cyclical pattern (e.g. 200 mg for 14 days each month). Confirm any cycle by email so the prescription matches.

If you're moving to the UK from a country where injectable progesterone was prescribed (US clinics sometimes use it off-label), we can help you transition onto oral or rectal capsules during your initial consultation. Bring your most recent prescription and bloods so we can plan continuity.

FREQUENTLY ASKED

## Questions, answered.

This guide isn't a substitute for clinical advice. We'll talk you through everything at your appointment.

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