---
title: "Progesterone Therapy Guide | The Gender Hormone Clinic"
description: "An optional nightly add-on after the first 12 months of feminising HRT, for mood, sleep, and breast maturation."
url: https://thegenderhormoneclinic.com/patient-resources/medication-guides/progesterone-therapy/
---

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PROGESTERONE · MEDICATION GUIDE

# Progesterone Therapy therapy, a clear guide.

Progesterone is offered as an optional add-on to feminising hormone therapy, typically after at least 12 months on oestrogen. Patients add it for one or more reasons: anecdotal reports of improved mood, better sleep, libido changes, and breast maturation.

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Drug class

Body-identical micronised progesterone

Used for

Optional feminising add-on

Frequency

Nightly (or cyclical)

Typical dose

100-200 mg nightly

Brands

Utrogestan, Gepretix (interchangeable)

Route

Oral (or rectal if GI side-effects)

On this page[Overview](#ma-overview)[Side effects](#ma-side-effects)[Cost](#ma-cost)[FAQ](#ma-faq)

OVERVIEW

## What progesterone therapy does, in plain English.

We use body-identical micronised progesterone, branded as Utrogestan (Besins Healthcare) or Gepretix (Exeltis). They are clinically equivalent and either may be substituted by your pharmacy.

If side effects from oral dosing are a problem, rectal administration of the same capsules is an option. Cyclical regimens (e.g. 200 mg × 14 days/month) are sometimes used.

SIDE EFFECTS & RISKS

## What to watch for, and what to tell us.

Most patients tolerate progesterone well; the main side effect is drowsiness, which is why we recommend taking it at night.

Common

Drowsiness +

Usually why we recommend taking it at night.

Mild dizziness +

Often resolves over the first few weeks.

GI upset +

Take on an empty stomach or rectally if oral dosing is difficult.

Bowel looseness +

Most often early; often resolves with time.

Occasional fatigue +

Usually mild and tolerable.

Less common / serious

VTE risk +

Progesterone may modestly increase VTE risk in some patients. Paused if you have other VTE risk factors.

COST

## What progesterone therapy costs you, monthly.

Affordable privately; even cheaper on shared care.

Utrogestan / Gepretix 100 mg

~£30 per month

Private prescription

Higher / cyclical dosing

£54-£55 per month

200 mg or cyclical

Once on shared care

£9.90 per item

Standard NHS Rx charge

[See full payment plan](https://thegenderhormoneclinic.com/patient-resources/payment-plans/)

FREQUENTLY ASKED

## Questions, answered.

This guide isn't a substitute for clinical advice. We'll talk you through everything at your appointment.

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## Ready to take the first step?

Send us an enquiry and we'll be in touch within two working days.

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