---
title: "Progynova Shortage: Alternatives Guide | The Gender Hormone Clinic"
description: "What to do if your pharmacy can't source Progynova: alternatives, dose equivalence, and how to switch safely."
url: https://thegenderhormoneclinic.com/patient-resources/medication-guides/progynova-shortage-alternative/
---

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SHORTAGE GUIDANCE · MEDICATION GUIDE

# Progynova Shortage: Alternatives therapy, a clear guide.

Progynova (estradiol valerate tablets) has been affected by intermittent UK supply shortages, most often during global manufacturing constraints. If your pharmacy can't fulfil a prescription, please don't skip doses or self-substitute. Contact us before you run out and we'll arrange a clinically equivalent replacement, usually the same day.

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First step

Don't skip doses; contact us before you run out

Active ingredient

Estradiol valerate (oral oestradiol)

Common substitutes

Zumenon, Sandrena gel, Evorel patches

Turnaround

Same-day or next working day

Cost on plan

Replacement script free on £55/month plan

Cost PAYG

£59 per new private prescription

On this page[Overview](#ma-overview)[FAQ](#ma-faq)

OVERVIEW

## What progynova shortage: alternatives does, in plain English.

Email or call us with your remaining supply (a photo of the box helps) and we'll void any expired prescription and re-issue a clinically equivalent one. Same-day turnaround is usually possible if you reach us during clinic hours; out of hours, expect a response by the next working day.

The most common substitution is Zumenon, the same active ingredient (estradiol valerate) under a different brand, with no clinical difference in effect. If that's also unavailable, your clinician may recommend switching route entirely to Sandrena gel or Evorel patches. Transdermal routes carry a lower VTE risk than oral oestradiol, so this can be a good moment to discuss whether a permanent switch makes sense for you.

If you've run out completely and can't reach us, Boots and Asda tend to have the most reliable supply for oestradiol products; smaller independent chemists vary widely. Do not buy from unverified online sources. Counterfeit hormones are a documented risk and dose accuracy cannot be guaranteed.

FREQUENTLY ASKED

## Questions, answered.

This guide isn't a substitute for clinical advice. We'll talk you through everything at your appointment.

[Make an enquiry](https://thegenderhormoneclinic.com/make-an-enquiry/)

## Ready to take the first step?

Send us an enquiry and we'll be in touch within two working days.

[Make an enquiry](https://thegenderhormoneclinic.com/make-an-enquiry/)