---
title: "Gender-Affirming HRT | The Gender Hormone Clinic"
description: "Nurse-led feminising, masculinising and non-binary hormone therapy for trans adults: started gently, monitored with blood tests, and shaped around your goals."
url: https://thegenderhormoneclinic.com/transgender-hormone-therapy/
---

# Hormone therapy, shaped around you.

Gender-affirming hormone therapy helps your body better reflect who you are. There is no single right way to do it: the right plan is the one that matches your goals, at a pace that feels right for you. We are an adults-only service (18+), and we will be alongside you the whole way.

Choose your path

## Pick the path that fits your goals.

[

Transfeminine / AMAB

### Feminising therapy

Oestrogen-based care, with a testosterone blocker and progesterone where they help.

Explore

](https://thegenderhormoneclinic.com/transgender-hormone-therapy/transfeminine/)[

Transmasculine / AFAB

### Masculinising therapy

Testosterone, by daily gel or longer-acting injection, adjusted to you.

Explore

](https://thegenderhormoneclinic.com/transgender-hormone-therapy/transmasculine/)[

Non-binary

### Non-binary & microdosing

Lower-dose, goal-led options for when you want some changes and not others.

Explore

](https://thegenderhormoneclinic.com/transgender-hormone-therapy/non-binary/)

Considering hormone blockers, or under 18? Please read [our position](https://thegenderhormoneclinic.com/transgender-hormone-therapy/hormone-blockers/) first.

How we keep it safe

## How we keep your care safe.

### We start low and adjust

You begin on a modest dose and we build up gradually, guided by how you feel and what your bloods show.

### Blood tests guide everything

Regular monitoring keeps your levels in a healthy range and catches anything that needs attention early.

### Reviews built in

Every six months for your first two years, then yearly once you are settled.

### Aligned with WPATH SOC 8

Delivered by an experienced, CQC-registered, nurse-led team.

Your medication

## Medication guides

Plain-English guides to every hormone, blocker and add-on we prescribe: how to take it, what to expect, and how we keep it safe.

[

Masculinising HRT

### Testosterone

A clear guide to testosterone therapy: what it does, how it's taken, and what to expect.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/testosterone-therapy/)[

Testosterone injection (3-weekly)

### Sustanon Injections

A blend of four testosterone esters delivered by intramuscular injection every 3 weeks.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/sustanon-injections/)[

Long-acting testosterone (12-weekly)

### Nebido Injections

A long-acting testosterone undecanoate injection given every 12 weeks for stable serum levels.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/nebido-injections/)[

Daily oestradiol gel

### Estrogen Therapy

A daily oestradiol gel applied to the inner thighs or lower abdomen, our default starting point for feminising HRT.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/estrogen-therapy/)[

Testosterone blocker

### Testosterone Blockers

The medicines that lower or block testosterone alongside oestrogen: GnRH analogues, cyproterone, spironolactone and bicalutamide.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/testosterone-blockers/)[

Injectable testosterone blocker

### GnRH Analogue Injections

Prostap, Decapeptyl and Zoladex: long-acting injectable blockers that suppress testosterone at the source, given every 4–12 weeks.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/gnrh-analogue-injections/)[

Optional progesterone add-on

### Progesterone Therapy

An optional nightly add-on after the first 12 months of feminising HRT, for mood, sleep, and breast maturation.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/progesterone-therapy/)[

Shortage guidance

### Progynova Shortage: Alternatives

What to do if your pharmacy can't source Progynova: alternatives, dose equivalence, and how to switch safely.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/progynova-shortage-alternative/)[

Shortage guidance

### Sustanon Shortage: Alternatives

What to do if Sustanon isn't available at your pharmacy: substitutes, schedules, and how to bridge safely.

Read guide

](https://thegenderhormoneclinic.com/patient-resources/medication-guides/sustanon-shortage-alternative/)

[See all medication guides](https://thegenderhormoneclinic.com/patient-resources/medication-guides/)

Before you start

## A note on fertility

Hormone therapy can affect your fertility, sometimes permanently, and it is not a form of contraception. If having biological children might matter to you, it is worth thinking about preservation before you start. We will talk it through with you and write any letters you need.

[Fertility preservation](https://thegenderhormoneclinic.com/transgender-care-services/fertility-preservation/)

Common questions

## Questions, answered.

Didn't find your answer?

[View all FAQs](https://thegenderhormoneclinic.com/patient-resources/faq/)

## Ready when you are.

Tell us a little about where you're at, and we'll guide your next step.

[Make an Enquiry](https://thegenderhormoneclinic.com/make-an-enquiry/)