Why can't I self-inject Nebido?

Nebido is a larger volume of oil delivered as a deep gluteal injection, and the technique requires care to avoid pulmonary microembolism. We have it administered by a clinician for safety.

When should I have my blood test?

At week 9 of the 12-week cycle (from the second dose onwards). Always note your last injection date on the form so we can interpret correctly.

How quickly will I see effects?

Roughly the same as other testosterone forms: voice and energy changes start within 3 months, fat redistribution and muscle by 6 months, hair patterns by 6-12. The smoothness is the key Nebido benefit.

Home / Medication guides / Nebido Injections

TRANS-MASCULINE HRT · MEDICATION GUIDE

Nebido Injections therapy, a clear guide.

Nebido provides one of the steadiest serum testosterone curves available, with peaks and troughs far less pronounced than with Sustanon. Because it's a larger volume of oil-based medication, Nebido must be administered by a healthcare professional.

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Drug class

Testosterone undecanoate

Route

Intramuscular (gluteal)

Loading

Doses at 0 and 6 weeks

Maintenance

Every 10-14 weeks

Self-administration

Not permitted

Trough target

10-20 nmol/L testosterone

OVERVIEW

What nebido injections does, in plain English.

Nebido contains testosterone undecanoate dissolved in castor oil. Compared with Sustanon, the half-life is much longer: your levels stay stable for months and the peak/trough swing is much smaller. NHS guidance associates it with a lower risk of polycythaemia than shorter-acting injections.

Patients typically begin with a loading dose, followed by a second dose at 6 weeks, then maintenance every 12 weeks. If menstrual bleeding returns near the end of a cycle, the interval may be shortened to 9-10 weeks.

SIDE EFFECTS & RISKS

What to watch for, and what to tell us.

Nebido is generally very well tolerated. Polycythaemia (raised haematocrit) is the main long-term safety marker we watch.

Common

Injection-site soreness +

For a couple of days after the injection. Rotate sides.

Acne and skin changes +

Usually milder than with shorter-acting esters. Settles after the first year.

Voice deepening +

Permanent. Begins around 3 months.

Cessation of menstruation +

Within the first 6 months for most patients.

Less common / serious

Polycythaemia +

Less common than with Sustanon, but still monitored every 6 months. Manage with hydration (≥2L/day), blood donation if eligible, or extending the interval to 12-14 weeks.

Pulmonary microembolism +

Rare but recognised: small oil droplets reaching the lung. Clinicians inject slowly to minimise the risk.

Monitoring schedule

We catch things early. Here's the routine you can expect.

Most of the testing is front-loaded while we fine-tune your dose. Once your levels are stable, it's usually just once a year.

Baseline

Full hormone panel

FBC, U&E, LFTs

Blood pressure

Week 9 of cycle

Trough testosterone

FBC (haematocrit)

LFTs

6-monthly while adjusting

Trough level

FBC, LFTs

Lipids

Yearly once stable

Full panel

BP, weight

Symptom review

COST

What nebido injections costs you, monthly.

Nebido has a higher unit cost than Sustanon, but only 4-6 doses per year are needed.

Nebido (private)

£130-£150 per dose

Professional admin only

Once on shared care

£9.90 per item

Standard NHS Rx charge

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Questions, answered.

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