Does progesterone help breast development?

Anecdotal reports suggest it may help with breast maturation, though high-quality evidence is limited. Many patients add it primarily for mood and sleep.

Is Gepretix the same as Utrogestan?

Yes. Both are body-identical micronised progesterone, clinically interchangeable. Pharmacy substitution between them is common.

When should I take it?

At night, on an empty stomach. Some patients prefer rectal administration if oral dosing causes GI upset or if blood levels matter for other reasons.

Home / Medication guides / Progesterone Therapy

PROGESTERONE · MEDICATION GUIDE

Progesterone Therapy therapy, a clear guide.

Progesterone is offered as an optional add-on to feminising hormone therapy, typically after at least 12 months on oestrogen. Patients add it for one or more reasons: anecdotal reports of improved mood, better sleep, libido changes, and breast maturation.

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Drug class

Body-identical micronised progesterone

Used for

Optional feminising add-on

Frequency

Nightly (or cyclical)

Typical dose

100-200 mg nightly

Brands

Utrogestan, Gepretix (interchangeable)

Route

Oral (or rectal if GI side-effects)

OVERVIEW

What progesterone therapy does, in plain English.

We use body-identical micronised progesterone, branded as Utrogestan (Besins Healthcare) or Gepretix (Exeltis). They are clinically equivalent and either may be substituted by your pharmacy.

If side effects from oral dosing are a problem, rectal administration of the same capsules is an option. Cyclical regimens (e.g. 200 mg × 14 days/month) are sometimes used.

SIDE EFFECTS & RISKS

What to watch for, and what to tell us.

Most patients tolerate progesterone well; the main side effect is drowsiness, which is why we recommend taking it at night.

Common

Drowsiness +

Usually why we recommend taking it at night.

Mild dizziness +

Often resolves over the first few weeks.

GI upset +

Take on an empty stomach or rectally if oral dosing is difficult.

Bowel looseness +

Most often early; often resolves with time.

Occasional fatigue +

Usually mild and tolerable.

Less common / serious

VTE risk +

Progesterone may modestly increase VTE risk in some patients. Paused if you have other VTE risk factors.

COST

What progesterone therapy costs you, monthly.

Affordable privately; even cheaper on shared care.

Utrogestan / Gepretix 100 mg

~£30 per month

Private prescription

Higher / cyclical dosing

£54-£55 per month

200 mg or cyclical

Once on shared care

£9.90 per item

Standard NHS Rx charge

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Questions, answered.

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